In biological dentistry, what is the biological mechanism of “PRF” (Platelet Rich Fibrin) technology in wound healing after tooth extraction?

In biological dentistry, after a tooth extraction, allowing the wound to heal on its own with an empty blood clot (especially if bone quality is poor) increases the risk of NICO or cavitation. To prevent this risk, “PRF” (Platelet-Rich Fibrin) technology is used. At the time of tooth extraction, a small tube of blood is taken from the patient and centrifuged at a special speed in the laboratory. While the red blood cells in the blood separate, a dense, jelly-like, natural “fibrin membrane” containing growth factors, leukocytes, and platelets is obtained. This PRF membrane is tightly placed inside the tooth extraction socket. For the next 7 days, PRF continuously releases a high concentration of growth factors into the wound area. This mechanism maximizes new blood vessel formation (angiogenesis) in the area, prevents infection, eliminates pain, and ensures complete bone healing without any cavities.

Updated date June 10, 2026

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